FORMULASI DAN UJI STABILITAS SEDIAAN TONER WAJAH EKSTRAK BUAH PARE (Momordica charantia L) SEBAGAI ANTI JERAWAT DENGAN VARIASI SURFAKTAN
DOI:
https://doi.org/10.33759/jrki.v5i1.330Keywords:
Acne, Bitter gourd extract, Facial toner, Polysorbate 20, StabilityAbstract
Bitter gourd extract (Momordica charantia L) contains secondary metabolites such as flavonoids, alkaloids, and saponins that can be antibacterial against acne-causing bacteria (Propionibacterium acnes). Momordica charantia L., could make into facial toner preparations to prevent the emergence and worsen acne. It is formulated with various concentrations of polysorbate 20 and performs stability testing. This study aimed at the optimal formula and analyzed the variations in the concentration effect of polysorbate 20 on the bitter gourd extract facial toner preparation. Bitter gourd extract would make into facial toner preparation with variations in the concentration of polysorbate 20. The accelerated stability test with the cycling test method includes before and after organoleptic, homogeneity, viscosity, and pH tests. The organoleptic stability result shows both stable formulas had the same liquid form, clear brown color, and characteristic rose odor. All formulations are stable on homogeneity, in which the particles are evenly mixed. The Formula I viscosity value is constantly stabilized and meets the parameters, while formula II is not but meets the parameters. The pH stability values of both formulas are stable and meet the parameters. Formula I is more optimal than formula II and the difference in surfactant concentration of polysorbate 20 has no effect on organoleptic, homogeneity, and pH but will affect viscosity.
Downloads
References
Benson, H. A. E., Roberts, M. S., Leite-Silva, V. R., & Walters, K. A. (2019). Cosmetic Formulation. In Cosmetic Formulation. https://doi.org/10.1201/9780429190674
Dinda. (2019). Uji Stabilitas Fisik dan Praklinis Face Toner Berbasis Kolagen dari Kulit Ikan Kakap Merah (Lutjanus sp.) dan Kitosan. https://repository.ipb.ac.id/handle/123456789/97336
Dominica, D., Handayani Prodi, D. S., Matematika dan Ilmu Pengetahuan Alam, F., & Bengkulu, U. (2019). Formulasi dan Evaluasi Sediaan Lotion dari Ekstrak Daun Lengkeng (Dimocarpus Longan) sebagai Antioksidan. JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA, 6(1), 1–7. https://doi.org/10.20473/JFIKI.V6I12019.1-7
Draelos, Z. D. (2019). Cosmeceuticals: What’s Real, What’s Not. In Dermatologic Clinics (Vol. 37, Issue 1, pp. 107–115). https://doi.org/10.1016/j.det.2018.07.001
Dreno, B., Gollnick, H. P. M., Kang, S., Thiboutot, D., Bettoli, V., Torres, V., & Leyden, J. (2015). Understanding Innate Immunity and Inflammation in Acne: Implications for Management. Journal of the European Academy of Dermatology and Venereology, 29(S4), 3–11. https://doi.org/10.1111/jdv.13190
Dwyer, J. M., Lavoie, J., O’Donnell, K., Marlina, U., & Sullivan, P. (2011). Contracting for Indigenous Health Care: Towards Mutual Accountability. Australian Journal of Public Administration, 70(1), 34–46. https://doi.org/10.1111/j.1467-8500.2011.00715.x
Habeshian, K. A., & Cohen, B. A. (2020). Current Issues in The Treatment of Acne Vulgaris. Pediatrics, 145(2). https://doi.org/10.1542/PEDS.2019-2056L
Heny Ekawati Haryono. (2019). KIMIA DASAR. DEEPUBLISH.
Mardhiani, Y. D., Yulianti, H., Azhary, D., Rusdiana, T., Farmasetika, R. B., Farmasi, T., Tinggi, S., Bandung, F., & Soekarno-Hatta Bandung, J. (2017). FORMULASI DAN STABILITAS SEDIAAN SERUM DARI EKSTRAK KOPI HIJAU (Coffea canephora var. Robusta) SEBAGAI ANTIOKSIDAN. INDONESIA NATURAL RESEARCH PHARMACEUTICAL JOURNAL, 2(2), 19–33. https://doi.org/10.52447/INSPJ.V2I2.910
Noval, & Malahayati, S. (2016). Teknologi Penghantaran Obat Terkendali. In Pena Persada (Issue April).
Pongsakornpaisan, P., Lourith, N., & Kanlayavattanakul, M. (2019). Anti-Sebum Efficacy of Guava Toner: A Split-Face, Randomized, Single-Blind Placebo-Controlled Study. Journal of Cosmetic Dermatology, 18(6), 1737–1741. https://doi.org/10.1111/jocd.12943
Rachmawati, D., & Asmawati, A. (2018). Uji Aktivitas Ekstrak Buah Pare (Momordica Charantia L) Terhadap Pertumbuhan Propionibacterium Acnes. Media Farmasi, 14(2), 32. https://doi.org/10.32382/mf.v14i2.590
Sari, D. Y., Ariansyah, S., Shinta, S., & Beniardi, W. (2021). Face Tonic Formulation From Ethanol Extract of Maranta arundinacea L. With Variety of Cosolvent and Surfactant: Propylene Glycol and Polysorbate 80. 27th International Conference ADRI, 34–39. https://doi.org/10.26737/adri27
Septian Laianto, Rafika Sari, L. P. (2014). Uji Efektivitas Sediaan Gel Anti Jerawat Ekstrak Etanol Buah Pare (Momordica Charantia) terhadap Staphylococcus Epidermidis dan Propionibacterium Acnes dengan Metode Difusi. 634. https://hsgm.saglik.gov.tr/depo/birimler/saglikli-beslenme-hareketli-hayat-db/Yayinlar/kitaplar/diger-kitaplar/TBSA-Beslenme-Yayini.pdf
Sjarif M. Wasitaatmadja. (2018). Akne. In Fakultas Kedokteran Universitas Indonesia.