FORMULASI KAPSUL ANTIDIABETES EKSTRAK UMBI BAWANG DAYAK (Eleuhterine palmifolia (L) Merr.) DENGAN VARIASI KONSENTRASI AVICEL 101 DAN PREGELATINIZED STARCH
DOI:
https://doi.org/10.33759/jrki.v5i3.402Abstract
Diabetes Mellitus is a heterogeneous disease characterized by improvement glucose levels in the blood. Several studies have shown that Dayak onions have hypoglycemic activity or lowering blood glucose levels which may be very useful for treatment of diabetes mellitus. Flavonoids contained in Dayak onions are in position to restore the characteristics of pancreatic tissue by increasing insulin release through β cells, so that it can lower blood sugar levels and can also increase sensitivity peripheral cells to insulin. Given the great potential of Dayak onions as antidiabetic, it is very important to develop more practical preparations that can carrying out weight uniform measurements of the products used, of course, one of them is in pharmaceutical preparations capsule form. This examination aims to determine the physical properties and antioxidant activity of Dayak onion extract capsules in large quantities concentration of Avicel PH 101 and pregelatinized starch as fillers. Look was carried out experimentally using three formulas with various concentrations fillers with a ratio between Avicel PH 101 and pregelatinized starch, in particular formula I (1:0), formulation II (0.5:0.5) and method III (0:1). body residence and drug stability is checked and then tested for antioxidant hobby spectrophotometric use. The research results show that the formula with the composition of Avicel PH 101 and pregelatinized starch in the ratio (0:1) is given the best wet house physical test results were 3.4%, sliding houses 12.82 gram/second, angle of repose 29.85⁰, compressibility 8%, density 0.544 and destroyed time 3 minutes 37 seconds. along with antioxidant effects activity examination showed that the drug Dayak onion extract proved to be moderate antioxidant activity, specifically 228.78 ppm.
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References
Ajie, B. R., 2015, White Dragon Fruit (Hylocereus undatus) Potential As Diabetes Mellitus Treatment, Jurnal Majority, 4(1).
Departemen Kesehatan Republik Indonesia., (1979), Farmakope Indonesia. Ed.lll. Jakarta: Departemen Kesehatan Republik Indonesia.
Departemen Kesehatan Republik Indonesia., (2014). Farmakope Indonesia edisi V. Jakarta: Departemen Kesehatan Republik Indonesia.
Devi IA, Shodiquna QA, Eni NW., (2018), Optimasi Konsentrasi Polivinil Pirolidon (PVP) Sebagai Bahan Pengikat Terhadap Sifat Fisik Tablet Ekstrak Etanol Rimpang Bangle (Zingiber cassumunar Roxb). Jurnal Farmasi Udayana. 7(2) : 45-52.
Dewi, N. P., Allia, R. dan Sabang, S. M., (2016), Uji Efektivitas Antidiabetes (Eleutherine Bulbosa (MILL.) URB. Terhadap Penurunan Kadar Glukosa Darah Tikus Obesitas, in Prosiding Seminar Nasional Tumbuhan Obat Indonesia Ke-50. Samarinda.
Farida, S., Mana, T. A., dan Dewi, T. F. (2019). Quality Profiling of Capsule Preparation for Physical Improvement Herbs in Saintifikasi Jamu. Jurnal Tumbuhan Obat Indonesia, 12(1), 25–32.
Gloria, M., dan Elisa, Y., (2018), Tekknologi sediaan solid. Edited by Elang Krisnadi. Kementrian Kesehatan Republik Indonesia.
Handayani, H., and F.H Sriherfyna., (2016), Ekstraksi Antioksidan Daun Sirsak Metodee Ultrasonik Bath (Kajian Rasio Bahan : Pelarut dan Lama Ekstraksi). Jurnal Pangan dan Agroindustri, 4(1):262-272.
Hasni Y., (2020), Pengaruh Ekstrak Umbi Bawang Dayak (Eleutherine bulbosa (Mill) Urb) Terhadap Kadar Glukosa Darah, Insulin dan Histopatologi Pankreas Tikus Wistar Diabetes Yang Diberikan Diet Tinggi Lemak dan Diinduksi dengan Streptozotocin, Skripsi, Fakultas Farmasi, Universitas Sumatra Utara.
Kelly GS., 2011, Quercetin, Journal Alternative Medicine Review, 16(2), 172-194.
Kementerian Kesehatan Republik Indonesia, (2017), Farmakope Herbal Indonesia edisi II, Kementerian Kesehatan Republik Indonesia, Jakarta.
Kusumo, N., N., Mita, S., R., (2016), Pengaruh Natural Binder Pada Hasil Granulasi Paracetamol, Farmaka Suplemen, 14(1).
Ladeksa, V. et al., (2020), Analisis Fisikokimia dan Aktivitas Antioksidan Umbi Bawang Bombay (Allium cepa L.), Jurnal Jamu Indonesia, 5(2), 56-57.
Mariyani, K., S., Arisanti, I., S., Setyawan, E., I., (2012), Pengaruh Konsentrasi Amilum Jagung Pregelatinasi Sebagai Bahan Penghancur Terhadap Sifat Fisik Tablet Vitamin E Untuk Anjing, Skripsi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Udayana.
Nurjanah, F., Sriwidodo., Nurhadi, B., (2021), Stabilisasi Tablet Yang Mengandung Zat Aktif Bersifat Higroskopis, Majalah Farmasentuka, 6 (1), 10-22.
Padila, S., (2018), Buku Ajar Keperawatan Medikal Bedah. Cet. 2. Yogyakarta: Nuha Medika.
Pahwa R., Gupta N., (2011), Superdisintegrants In The Development Of Orally Disintegrating Tablets: A Review, International Journal Of Pharmaceutical Sciences And Research, 2(11), 2767-2780.
Prawitasari, D., S., (2019), Diabetes Melitus dan Antioksidan, Jurnal Kesehatan dan Kedokteran, 1(1), 47-51.
Romsiah, et al., (2020), Perbandingan Aktivitas Antioksidan Ekstrak Bawang Putih (Allium sativum L.), Bawang Putih Tunggal (Allium sativum var. Solo Garlic) dan Black Garlic Dengan Metode DPPH, Jurnal Ilmiah Bakti Farmasi, 5(1), 45-50.
Roselyndiar., (2012), Formulasi Kapsul Kombinasi Ekstrak Herba Seledri (Apium graveolens L.) dan Daun Tempuyang (Sonchus arvensis L.), Skripsi, Fakultas Matematika Ilmu Pengetahuan Alam, Program Ekstensi Farmasi, Depok.
Sa’adah, H., Nurhasanawati, H., (2015), Perbandingan Pelarut Etanol dan Air Pada Pembuatan Ekstrak Umbi Bawang Tiwai (Eleutherine americana Merr.) Menggunakan Metode Maserasi, Jurnal Ilmiah Manuntung, 1(2), 149-153.
Sa’adah, H., Supomo., Siswanto, E., Kintoko., Witasari, H. A., (2021), Formulasi Sediaan Tablet Ekstrak Akar Kuning (Fibraurea tinctoria Lour.) Sebagai Antidiabetes, Jurnal Ilmiah Manuntung, 7(2), 182-188.
Torok, B. et al., Effectiveness Of Garlic On The Radical Activity In Radical Generating Systems, Arzneimittelforschung, 1994; 44(5), 608-611.
Sasmita, F. W. et al., (2017), Efek Ekstrak Daun Kembang Bulan (Tithonia diversifolia) terhadap Kadar Glukosa Darah Tikus Wistar (Rattus norvegicus) yang Diinduksi Alloxan, Biosfera, 34(1), p. 22. doi: 10.20884/1.mib.2017.34.1.412.
Wicaksono, Y., dan Syifa’, N., 2012, Pengembangan Pati Singkong-Avicel P 101 menjadi Bahan Pengisi Co-Process Tablet Cetak Langsung. Majalah Farmasi Indonesia.
Williams JC and TA., (2015), Handbook of Powder Technology Granulation.
Winarsi H, Dwi Sasongko N, Purwanto A, Nuraeni I., (2013), Ekstrak Daun Kapulaga Menurunkan Indeks Atherogenik dan Kadar Gula Darah Tikus Diabetes Induksi Aloxan, Agritech: Jurnal Fakultas Teknologi Pertanian UGM, 33(3), pp. 273–280. doi: 10.22146/agritech.9548.
Yuswi, et al., (2017), Ekstraksi Antioksidan Bawang Dayak (Eleutherine palmifolia) Dengan Metode Ultrasinic Bath (Kajian Jenis Pelarut dan Lama Ekstraksi), Jurnal Pangan dan Agroindustri, 5(1), 71-79.
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