UJI EFEK ANTIPIRETIK EKSTRAK ETANOL BIJI KORO BENGUK (Mucuna pruriens L.) DENGAN METODE SOKHLETASI PADA TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus L.)
DOI:
https://doi.org/10.33759/jrki.v6i1.417Keywords:
Anti Piretik, Koro Benguk, SokhletasiAbstract
Mucuna pruriens L is a plant that lives in a tropical climate and is widely found in Indonesia. Public knowledge on how to use velvet bean is still limited. Mucuna pruriens L plants have benefits such as antibacterial, gout, cancer, diabetes, kidney stones. The purpose of this study was to determine the effectiveness and antipyretic effect of Mucuna pruriens L ethanol extract. This study used the socleation method as an extraction method. Velvet Mucuna pruriens L ethanol extract was given orally to male white rats. The administration of extracts was divided into 5 groups, namely group 1 given CMC-Na as a negative control, group II paracetamol 45 mg / kg BB, group III 200 mg / KgBB and group IV 300 mg / KgBB and group V 400 mg / KgBB. The body temperature of the rats was measured at intervals of 30 minutes to 150 minutes when they were given the test substance orally. Based on research analysis showed that at a dose of 400 mg / KgBB mhad a comparable entipyretic effect strength in positive controls. Therefore, Mucuna pruriens L have potential as antipyretic drugs.
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Avoseh, O. N., Ogunwande, I. A., Ojenike, G. O., & Mtunzi, F. M. (2020). Volatile Composition, Toxicity, Analgesic, and Anti-Inflammatory Activities of Mucuna pruriens. Natural Product Communications, 15(7), 1934578X2093232. https://doi.org/10.1177/1934578X20932326
Budiyati, E., Mulyono, P., & Purwono, S. (2013). Pengaruh Diameter Partikel terhadap Konsentrasi L-DOPA, kC dan De pada Ekstraksi L-DOPA dari Biji Kara Benguk (Mucuna pruriens DC.)(Effect of Particle’s Diameter to L-DOPA Concentration, kC, And De In the Extraction L-DOPA from Mucuna pruriens’s SEED). https://publikasiilmiah.ums.ac.id/xmlui/handle/11617/6141
Gandjar, I., Slamet, D. S., & Moeljono, M. (1973). Kadar zat gizi dalam tempe benguk. Penelitian Gizi dan Makanan (The Journal of Nutrition and Food Research). https://pgm.persagi.org/index.php/pgm/article/view/139
Harbourne, J. B. (2002). Metode Fitokimia: Penuntun Cara ModernMenganalisis Tumbuhan, Diterjemahkan Oleh K. Padmawinata Dan I. Soediro. ITB. Bandung.
Jansen, I., Wuisan, J., & Awaloei, H. (2015). Uji efek antipiretik ekstrak meniran (Phyllantus niruri L.) pada tikus wistar (Rattus norvegicus) jantan yang diinduksi vaksin DPT-HB. eBiomedik, 3(1). https://ejournal.unsrat.ac.id/v3/index.php/ebiomedik/article/view/7427
Jóźwiak-Bebenista, M., & Nowak, J. Z. (2014). Paracetamol: Mechanism of action, applications and safety concern. Acta poloniae pharmaceutica, 71(1), 11–23.
Khosideh, K. (2017). Uji aktivitas antikanker ekstrak dan fraksi biji Koro Benguk (Mucuna pruriens (L) DC). Var pruriens terhadap HeLa cell line kanker serviks [PhD Thesis, Universitas Islam Negeri Maulana Malik Ibrahim]. http://etheses.uin-malang.ac.id/13869/
Mardianingrum, R. (2019). Uji Antipiretik Minyak Atsiri dan Ektrak Metanol Rimpang Bangle (Zingiber purpureum R) pada Mencit Jantan Galur Swiss Webster. semnaskes 2019, 92–97.
Pramita, D. S., Handajani, Sri., & Rachmawanti, D. (2008). The effect of heating technique to phytic acid content and antioxidant activity of velvet bean (Mucuna pruriens), butter bean (Phaseolus lunatus) and jack bean (Canavalia ensiformis). Asian Journal of Natural Product Biochemistry, 6(2), 36–44.
Puspitasari, A. D., & Proyogo, L. S. (2017). Perbandingan metode ekstraksi maserasi dan sokletasi terhadap kadar fenolik total ekstrak etanol daun kersen (Muntingia calabura). Cendekia Eksakta, 2(1). https://publikasiilmiah.unwahas.ac.id/index.php/CE/article/view/1791
Retnaningsih, C., Widowati, W., & Soeng, S. (2008). Laporan penelitian: Potensi Fraksi Aktif Antioksidan, Antikolesterol Kacang Koro (Mucuna Pruriens L.) Dalam Pencegahan Aterosklerosis. Http://Repository.Unika.Ac.Id/2355
Rezaldi, F., Khodijah, S., & Sumarlin, U. S. (2022). Formulasi dan Uji Efektivitas Sediaan Sirup Ekstrak Daun Kacapiring (Gardenia jasminoides J. Ellis) Sebagai Antipiretik Terhadap Mencit (Mus musculus L) Yang Di Induksi Vaksin DPT. Jurnal Biogenerasi, 7(1), 1–16.
RI, D. P. D. (1995). Farmakope Indonesia. Edisi IV. Depkes RI. Jakarta. hlm, 7. https://dev-sisobat.pom.go.id/assets/standard/Suplemen_I_Farmakope_Indonesia_Edisi_VI.pdf
Samiun, A., De Queljoe, E., & Antasionasti, I. (2020). Uji efektivitas senyawa flavonoid dari ekstrak etanol daun sawilangit (Vernonia cinerea (l.) less) sebagai antipiretik pada tikus putih jantan galur wistar (Rattus norvegicus) yang diinduksi vaksin DPT. Pharmacon, 9(4), 572–580.
Shilpi, J. A., & Uddin, S. J. (2020). Analgesic and antipyretic natural products. Dalam Annual Reports in Medicinal Chemistry (Vol. 55, hlm. 435–458). Elsevier. https://www.sciencedirect.com/science/article/pii/S0065774320300129
Tari, M., Ramadhiani, A. R., & Marwanti, E. (2019). Uji aktivitas analgetik-antipiretik ekstrak etanol daun karamunting (Rhodomytrus tomentosa (Aiton) Hassk) terhadap tikus putih jantan galur wistar. Jurnal’Aisyiyah Medika, 4. http://jurnal.stikes-aisyiyah-palembang.ac.id/index.php/JAM/article/view/240
Tavares, R. L., Silva, A. S., Campos, A. R. N., Schuler, A. R. P., & de Souza Aquino, J. (2015). Nutritional composition, phytochemicals and microbiological quality of the legume, Mucuna pruriens. African Journal of Biotechnology, 14(8), 676.
Utami, N. F., Sutanto, S., Nurdayanty, S. M., & Suhendar, U. (2020). Pengaruh berbagai metode ekstraksi pada penentuan kadar flavonoid ekstrak etanol daun iler (Plectranthus scutellarioides). FITOFARMAKA: Jurnal Ilmiah Farmasi, 10(1), 76–83.
Wijayanti, R., & Rosyid, A. (2018). Efek Antipiretik Ekstrak Kulit Umbi Bawang Putih (Allium sativum, L) Dan Pengaruhnya Terhadap Kadar Sgot Dan Sgpt Tikus Putih (Rattus norvegicus) Yang Diinduksi Vaksin DTP-HB-Hib. Cendekia Journal of Pharmacy, 2(1), 39–49.
Wismananda, A. V., Safithri, F., & Pravitasari, D. N. (2018). Uji Efek Antipiretik Air Perasan Rimpang Jahe Merah (Zingiber officinale var. Rubrum) pada Tikus Putih (Rattus norvegicus) Jantan Galur Wistar yang Diinduksi Ragi Roti. Herb Medicine Journal, 1(2), 86–91.
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