UJI AKTIVITAS SITOTOKSIK EKSTRAK METANOL BUAH KETUMBAR (Coriandrum sativum Linn) TERHADAP ARTEMIA SALINA LEACH DENGAN UJI BSLT (Brine Shrimp Lethality Test)
DOI:
https://doi.org/10.33759/jrki.v2i3.72Keywords:
Ketumbar, Coriandrum sativum, Sitotoksik, BSLTAbstract
Coriander is a common herb can be used as traditional medicine. One of the expected benefits of Coriander fruits is an anti-cancer. This study aims to determine the cytotoxic activity of Coriander extract (Coriandrum sativum Linn) on shrimp larvae (Artemia salina Leach) with the BSLT (Brine Shrimp Lethality Test) method. Coriander fruits was extracted using methanol solvent and maceration method, then concentrated it with a rotary evaporator until a thick extract. Cytotoxic activity test used methanol extract with several concentration : 1,000 ppm, 100 ppm, 10 ppm, and 1 ppm. The result of this research reveal that methanol extract of Coriander fruits has cytotoxic activity with LC50 value is 32.35 ppm.
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References
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Tianandari F& Rasidah R. (2017).Uji stitotoksik ekstrak etanol buah ketumbar (Coriandrum Sativum Linn) terhadap artemia salina leach dengan metode BSLT. Action: Aceh Nutrition Journal, 2(2), 86-90.
Anonim. (2008). Parameter standar umum ekstrak tumbuhan obat, Cetakan 1. Departemen Kesehatan RI, Jakarta.
Dirgantara S, Rosye HRT, Hendra KM, Edy M. (2018). Cytotoxic activity and phytochemical analysis of breynia cernua from Papua. Indonesian Journal of Pharmaceutical Science and Technology, 1(1), 31-36.
Djamal, R. (2010). Kimia bahan alam : prinsip-prinsip dasar isolasi dan identifikasi.Universitas Baiturrahma, Padang.
Faridah, I. (2012).Uji praskrinning aktivitas antikanker daun kembang bokor (Hydragea mamophylla) dengan metode BSLT. Skripsi, Universitas Muhammadiyah Malang.
Harmita & Radji M.(2008). Analisi hayati. Jakarta: Buku Kedokteran EGC.
Iqbal J, Banzeer AA, Tariq M et al. (2017). Plant-derived anticancer agents : A green anticancer approach. Asian Pacific Journal of Tropical Biomedicine, 7(12): 1129-1150.
Majeed W, Bilal A, Ijaz Javed et al. (2014). Breast cancer major risk factors and recent development intreatment. Asian Pacific Journal of Cancer Prevention, 15, 3353-3358.
Mangan, Yellia.(2010). Sehat mencegah dan mengatasi kanker. Jakarta, Penerbit: Agromediapustaka.
Melo E A, Jorge MF & Nonete BG. (2004). Characterization of antioxidant compounds in aqueous coriander extract (Coriandrum Sativum L.). Elsevier, Swiss Society Food Science and Technology, 38, 15-19.
Mojo T, Jemmy A, Max RJR. (2016). Kajian toksisitas dari fraksi heksana, etil asetat, dan etanol daun soyogik (Sauraia bracteosa DC). Jurnal MIPA UNSRAT online, 5(1), 40-43.
Rajeshwari U & Bondada A. (2011). Medicinal benefit of coriander (Coriander Sativum L). Saptula DD,1(1), 51-58.
Rampe MJ & Joke LT. (2015). Pengujian fitokimia dan toksisitas ekstrak etanol jantung pisang kepok (Musa paradisiaca LINN.) dengan metode Brine Shrimp Lethality Test (BSLT). Jurnal Sainsmat, 136-147.
Suparni & Wulandari. (2012). 1001 Ramuan tradisional asli Indonesia.Rapha Publishing, Yogyakarta.
Syamsuni H.A. (2007). Ilmu galenica. EGC, Jakarta.
Sudewo B.(2012). Basmi kanker dengan herbal.Jakarta : Visimedia.
Sudiana I K.(2008). Patologi molekul kanker. Jakarta: Salemba Medika.
Tianandari F& Rasidah R. (2017).Uji stitotoksik ekstrak etanol buah ketumbar (Coriandrum Sativum Linn) terhadap artemia salina leach dengan metode BSLT. Action: Aceh Nutrition Journal, 2(2), 86-90.
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Published
2020-09-16
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UJI AKTIVITAS SITOTOKSIK EKSTRAK METANOL BUAH KETUMBAR (Coriandrum sativum Linn) TERHADAP ARTEMIA SALINA LEACH DENGAN UJI BSLT (Brine Shrimp Lethality Test). (2020). Jurnal Riset Kefarmasian Indonesia, 2(3), 137-146. https://doi.org/10.33759/jrki.v2i3.72
