EFEKTIVITAS GEL EKSTRAK ETANOL BAWANG PUTIH (Allium sativum L.) TERHADAP BAKTERI Staphylococcus aureus
DOI:
https://doi.org/10.33759/jrki.v2i2.84Keywords:
Gel, Bawang putih (Allium sativum L.), Staphylococcus aureus, antibakteri.Abstract
Garlic (Allium sativum L.) is one of the traditional medicines which has an antibacterial efficacy compound namely Allisin which is able to inhibit the growth of Staphylococcus aureus bacteria. This study aims to formulate the garlic bulb extract into a good gel preparation for use as an acne drug and to determine the antibacterial effectiveness of the ethanol extract of garlic gel against the bacterium Staphylococcus aureus using the wells method. The gel evaluation was carried out to meet the requirements with organoleptic test parameters, homogeneity, pH, spreadability, adhesion and irritation test. This study uses extracts of 10% and 20% concentrations, at each concentration being able to inhibit the growth of Staphylococcus aureus bacteria. In the formula, the concentration of 20% has a inhibition zone diameter of 1.59 cm and a concentration of 10% has a inhibition of 1.50 cm. Statistical test results using the One Way ANOVA test found that there was no significant difference between the average diameter of inhibition of garlic extract gel concentration of 10% with a concentration of 20%.
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References
Anggraeni, D., & Kamaluddin, H. M. T. (2018). Efektivitas Gel Ekstrak Air Bawang Putih ( Allium sativum . L ) Terhadap Kadar Tumor Necrotic Factor Alfa ( TNF- α ) Dan Diameter Ulkus Mulut Pada Tikus Putih Jantan Galur Wistar Ulkus mulut merupakan kondisi patologis yang ditandai dengan hilangnya jarin. Biomedical Journal of Indonesia, 4(3), 128–139.
Bayan, L., Koulivand, P. H., & Gorji, A. (2014). Garlic : a review of potential therapeutic effects. Avicenna Journal of Phytomedicine, 4(1), 1–14.
Genaro, R. . (1990). Rhemingtons Pharmaceutical Science (8th ed.). Mack Printing Company.
Harahap, & Marwali. (2000). Ilmu Penyakit Kulit. Hipokrates.
Ichsan, Z. (2009). Efek antibakteri ekstrak bawang putih (Allium sativum) terhadap pertumbuhan Streptococcus mutans secara in vitro. Universitas Sebelas Maret. Skripsi.
Iwalokun, B., Ogunledun, A., Ogbolu, D., Bamiro, S., & Omojola, J. (2004). In Vitro Antimicrobial Properties of Aqueous Garlic Extract Against Multidrug-Resistant Bacteria and Candida Species from Nigeria. Journal of Medicinal Food, 7(3), 327–334. https://doi.org/10.1089/1096620041938669
Les, L. H., Isnaeni, & Soeratri, W. (2017). Aktivitas Antibakteri dan Stabilitas Sediaan Gel Minyak Atsiri Daun Jeruk Purut (Citrus hystrix folium). Jurnal Farmasi Dan Ilmu Kefarmasian Indoensia, 4(2), 67–73.
Myles, I., & Datta, S. (2012). Staphylococcus aureus : an introduction. NIH Public Access, 34(2), 1–6. https://doi.org/10.1007/s00281-011-0301-9
Ningsih, W., Firmansyah, & Anggraini, S. (2016). Ekstrak Etanol Daun Kembang Bulan. Jurnal Ilmiah Farmasi, 2, 79–85.
Pelen, S., Wullur, A., & Citraningtyas, G. (2016). Formulasi Sediaan Gel Antijerawat Minyak Atsiri Kulit Batang akyu Manis (Cinnamomum burmanii) Dan Uji Aktivitas Terhadap Bakteri Staphylococcus aureus. Pharmacon, 5(4), 136–144.
Prihandani, S. S., Poeloengan, M., & Noor, S. M. (2015). Uji Daya Antibakteri Bawang Putih ( Allium sativum L .) Terhadap Bakteri Staphylococcus aureus , Escherichia coli , Salmonella typhimurium DAN Pseudomonas aeruginosa dalam Meningkatkan Keamanan Pangan. Informatika Pertanian, 24(1), 53–58.
Putra, R.E.D., Homenta, H. dan Wowor, V.N.S. 2017. Uji daya hambat perasan jeruk purut Citrus Hytrix terhadap bakteri Staphylocuccus aureus secara in vitro. Jurnal Ilmiah Farmasi. 6(1):65-66.
Ross, Z. M., Gara, E. A. O., Hill, D. J., & Sleightholme, H. V. (2001). Antimicrobial Properties of Garlic Oil against Human Enteric Bacteria : Evaluation of Methodologies and Comparisons with Garlic Oil Sulfides and Garlic Powder. Applied and Enviromental Microbiology, 67(1), 475–480. https://doi.org/10.1128/AEM.67.1.475
Salima, J. (2015). Antibacterial Activity of Garlic ( Allium sativum l .). J Majority, 4(2), 30–39.
Sampelan, M., Pangemanan, D., & Kundre, R. (2017). Hubungan Timbulnya Acne Vulgaris Dengan Tingkat Kecemasan Pada Remaja di SMP N 1 Likupang Timur. E-Journal Keperawatan, 5(1), 1–8.
