OPTIMASI PENGGUNAAN HPMC DAN Na CMC PADA FORMULA TRANSDERMAL PATCH EKSTRAK ETANOL BUNGA TELANG (Clitoria ternatea L.) DENGAN METODE SIMPLEX LATTICE DESIGN
DOI:
https://doi.org/10.33759/jrki.v4i3.224Keywords:
Transdermal patch, Clitoria ternatea L.,, Simplex Lattice Design, HPMC, Na CMCAbstract
Transdermal patch is drug delivery system that is pasted through the skin. These preparations can provide a constant drug release, easy to use, reduce the frequency of drug administration, eliminate first-pass metabolism, and reduce side effects such as gastric irritation and improve patient compliance. Blue pea (Clitoria ternatea L.) contains flavonoid compounds that have anti-inflammatory activity. This study aims to obtain the optimal comparison of HPMC and Na CMC as a polymer in the transdermal patch formula of the ethanol extract of the blue pea (Clitoria ternatea L.). Optimization was carried out using the Simplex Lattice Design method with Software Design Expert version 11. The responses used included pH tests, weight tests, thickness tests, folding tests and moisture content tests. The optimal formula obtained from the Simplex Lattice Design method was verified with the SPSS program using the one sample t-test method. The optimal formula of transdermal patch of blue pea ethanol extract was tested for acceptability to determine whether it was acceptable to the respondent or not. The optimal comparison of HPMC and Na CMC as a polymer with transdermal patch preparation of blue pea ethanol extract was 3.5%:1%, with a desirability value of 0.944.
Downloads
References
Andriani, D., Murtisiwi, L., 2018. Penetapan Kadar Fenolik Total Ekstrak Etanol Bunga Telang (Clitoria ternatea L.) dengan Spektrofotometri UV Vis. Cendekia Journal of Pharmacy, 2(1), 35.
Arunachalam, A., Karthikeyan, M., Kumar, D., Prathap, M., Sethuraman, S. dan Ashutoshkumar, S. (2010). Transdermal drug delivery system: a review, International Journal of Pharmaceutical Science and Research, 1(1), pp. 70-81.
Kalay, S., Bodhi, W., dan Yamlean, P., 2014, Uji Efek Antipiretik Ekstrak Etanol Daun Prasman (Eupatorium Triplinerve Vahl.) pada Tikus Jantan Galur Wistar (Rattus Norvegicus L.) yang di induksi Vaksin Dpt Hb, ISSN 2302-2493.
Kumar, S.V., Turun, P. dan Kumar T.A. (2013). Transdermal drug delivery system for nonsteroidal anti-inflammatory drugs: A review, Indo American Journal of Pharmaceutical Research, 3(5), pp. 3588-3605.
Kusrini, E., Tristantini, D., Izza, N., 2017. Uji Aktivitas Ekstrak Bunga Telang (Clitoria ternatea L.) sebagai Agen Anti-Katarak. Jurnal Jamu Indonesia, 2(1), 30.
Kuswindayanti, Ni Made. 2020. Efek Antiinflamasi Topikal Ekstrak Etanol Bunga Telang (Clitoria Ternatea L.) Terhadap Jumlah Sel Neutrofil Dan Ekspresi Cox-2 Pada Kulit Mencit Terinduksi Karagenin, Skripsi, Fakultas Farmasi Universitas Sanata Dharma. Yogyakarta.
Marpaung, Abdullah Muzi. 2020. Tinjauan Manfaat Bunga Telang (Clitoria ternatea L.) Bagi Kesehatan Manusia. Journal of Functional Food and Nutracetical. 1 (2), pp.1-23.
Rahim, F., Deviarny, C., Yenti, R. dan Ramadani, P., 2016. ‘Formulasi Sediaan Patch Transdermal Dari Rimpang Rumput Teki (Cyperus rotundus L .) Untuk Pengobatan Nyeri Sendi Pada Tikus Putih Jantan’, Scientia, 6(1), pp. 1–6.
Rowe, R.C., Paul, J.S., dan Marian, E.Q. (2009). Handbook of Pharmaceutical Excipient Sixth Edition. Pharmaceutical Press: London.
Stepi KA. Optimasi Konsentrasi HPMC sebagai matriks dan konsentrasi asam oleat sebagai enhancer dalam matriks patch tipical natrium diklofenak. Skripsi. Fakultas Farmasi, Unika Widya Mandala. Surabaya. 2011.
Suryani., Andi Nafisah., Syahrir Mana’an. 2017. Optimasi Formula Gel Antioksidan Ekstrak Etanol Buah Bligo (Benincasa hispida) dengan Metode Simplex Lattice Design (SLD). Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) 3 (2): 150 – 156.
Wuryaningtyas, Bidara Ayuna. 2017. Optimasi Formula Tablet Ekstrak Daun Yakon (Smallanthus sonchifolius (Poepp. & Endl.) H. Robinson) Dengan Bahan Pengikat Gelatin Dan Bahan Penghancur Metilselulosa Dengan Metode Simplex Lattice Design. Skripsi. Program Studi Farmasi Fakultas Farmasi Universitas Muhammadiyah Surakarta.
