UJI IN VIVO TAHAP PREKLINIS TERHADAP EKSTRAK BATANG PISANG (Musa paradisiaca L.) SEBAGAI ANTIINFLAMASI TOPIKAL
DOI:
https://doi.org/10.33759/jrki.v3i2.129Keywords:
Ekstrak, Batang pisang, Karagenan 1%Abstract
Inflammation is a normal protective response to tissue injury caused by physical trauma, chemical damage, or microbiological substances. Banana stems (Musa paradisiaca L.) have been empirically believed for their topical anti-inflammatory properties. The purpose of this study was to scientifically evaluate the in vivo preclinical anti-inflammatory activity of banana stems. This research was designed experimentally using twenty-five albino male rats which were divided into five groups: the positive control group which received sodium diclofenac gel, the negative control group which received gel basis preparation without any active ingredient, and three experimental groups which received banana stem extract gel in three different concentrations, 5%, 10%, and 15%. Every five rats of every group were firstly injected with 1% of carrageenan, and the anti-inflammatory effect was evaluated every hour for 4 hours using a plethysmometer. The collected data were statistically evaluated. The results showed that banana stem extract gel with concentrations of 15% produced the best anti-inflammatory effect, compared to other gel concentrations. In conclusion, the preparation of 15% banana stem extract gel can be applied as potential topical anti-inflammatory preparation.
Downloads
References
Departemen Kesehatan Republik Indonesia..(2010).Parameter Standar Umum Ekstrak Tumbuhan Obat. Departemen Kesehatan RI :Jakarta.
Harnis, Z. E., Sitorus, P., & Rosidah, R. (2018). Phytochemical Screening And Anti-Inflammatory Activity Of Fractions From Sambung Rambat (Micania cordata) Leaf. Asian J Pharm Clin Res, 11(8), 199-201.
Hasim, H., Arifin, Y. Y., Andrianto, D., & Faridah, D. N. (2019). Ekstrak Etanol Daun Belimbing Wuluh (Averrhoa bilimbi) sebagai Antioksidan dan Antiinflamasi. Jurnal Aplikasi Teknologi Pangan, 8(3), 86-93.Marhamah & Putri, IW., 2018, Efektivitas Ekstrak Batang Pisang Kepok (Musa x paradisiaca Linn.) Terhadap Pertumbuhan Bakteri Streptococcus pyogenes. Jurnal Analisis Kesehatan, vol. 7, no. 1.
Mirza, M., Amanah, S., & Sadono, D. (2017). Tingkat Kedinamisan Kelompok Wanita Tani dalam Mendukung Keberlanjutan Usaha Tanaman Obat Keluarga di Kabupaten Bogor, Jawa Barat. Jurnal Penyuluhan, 13(2), 181-193.Mohammed, MS, Osman,WJA, Garelnabi, EAE, Osman, Z, Osman, B, Khalid, HS & Mohamed, MA., 2014, Secondary Metabolites as Anti-inflammatory Agents,The Journal Of Phytopharmacology, no. 3, vol. 4, pp. 275-285.
Nurcholis, I. A., Yusriadi, Y., & Sulastri, E. (2019). Aktivitas Antiinflamasi Gel Ekstrak Rumput Mutiara (Ordelandia corymbosa L.) Pada Tikus (Rattus norvegicus L.) Yang Diinduksikan Karagenan. Biocelebes, 13(1).
Ogofure, A. G., & Emoghene, A. O. (2016). Evaluation of proximate, phytochemical and antibacterial properties of the pseudostem and hand of plantain (Musa paradisiaca). Nigerian Journal of Agriculture, Food and Environment, 12(2), 19-26.Rachmania, RA, Zikriah, R, Hariyanti, & Soultan, A., 2018, Studi In Silico Senyawa Alkaloid Herba Bakung Putih (Crinum Asiaticum L.) pada Penghambatan Enzim Siklooksigenase (COC). Jurnal Kimia Valenci, vol. 4, no. 2, pp. 124-136.
Sander, M. A. (2017). Atlas Berwarna Patologi Anatomi.
Sukmawati, S., Yuliet, Y., & Hardani, R. (2015). Uji aktivitas antiinflamasi ekstrak etanol daun pisang ambon (Musa paradisiaca L.) terhadap tikus putih (Rattus norvegicus L.) yang diinduksi karagenan. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy)(e-Journal), 1(2), 126-132.
