KAJIAN PUSTAKA FORMULASI DAN EVALUASI MIKROKAPSUL SALUT ENTERIK MENGGUNAKAN ACRYL-EZE® & SURETERIC DENGAN METODE PENGGABUNGAN MIKROENKAPSULASI DENGAN EKSTRUSI-SFERONISASI
DOI:
https://doi.org/10.33759/jrki.v2i3.89Keywords:
Ekstrusi-sferonisasi, Mikroenkapsulasi, Salut enterikAbstract
Microcapsules were prepared by means of microencapsulation modified by the extrusion-spheronization method. The extrusion-spheronization method is used to cover the shortcomings of the microencapsulation method. The results showed that Acryl-eze and Sureterik can be used in coatings in producing microcapsules. The results of research evaluating the formulation of enteric acetosal coated microcapsules have not resulted in delayed release system that is in accordance with monographic requirements and dissolution profile testing has not shown the elimination stage. The results of the evaluation of the delayed release release system enteric coated microcapsule formulation met the requirements of monograph and dissolution profile test results, except for F3 in buffering conditions. The purpose of this literature review is to examine the enteric-coated microcapsule formulation using Acryl-eze® & Sureteric by combining microencapsulation and spheronization extrusion methods.
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References
Cole, E. T. et al. (2002) ‘Enteric coated HPMC capsules designed to achieve intestinal targeting’, International Journal of Pharmaceutics, 231(1), pp. 83–95. doi: 10.1016/S0378-5173(01)00871-7.
El-Mahdi, I. M. and El-Shhibia, S. A. (2017) ‘Effect of spheronizer plate design on the spheronization of ketoprofen’, Future Journal of Pharmaceutical Sciences. Elsevier Ltd, 3(2), pp. 153–157. doi: 10.1016/j.fjps.2017.05.004.
Gangurde, A. et al. (2015) ‘Modified extrusion-spheronization as a technique of microencapsulation for stabilization of choline bitartrate using hydrogenated soya bean oil’, International Journal of Pharmaceutical Investigation, 5(4), p. 275. doi: 10.4103/2230-973x.167696.
Ravetti, S. et al. (2016) ‘Challenges in Protein Formulation Focused on Extrusion-Spheronization Process’, 5(3), pp. 29–38.
Santoso, R., Ziska, R. and Muzdalifah, D. (2019) ‘Formulasi dan Evaluasi Mikrokapsul Salut Enterik Lansoprazol Menggunakan Acryl-Eze® & Sureteric dengan Metode Ekstrusi dan Sferonisasi pada Era Jaminan Kesehatan Nasional’, Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan, 5(2). doi: 10.33772/pharmauho.v5i2.10169.
Santoso, R., Ziska, R. and Putra, A. D. (2019) ‘FORMULASI DAN EVALUASI MIKROKAPSUL SALUT ENTERIK ASETOSAL MENGGUNAKAN PENYALUT ACRYLEZE® 93O DENGAN METODE EKSTRUSI DAN SFERONISASI’, Jurnal Ilmiah Farmacy, 6(1), pp. 27–43. doi: 10.5281/zenodo.1477753.
Scala-bertola, J. et al. (2009) ‘Pellets for oral administration of low-molecular-weight heparin’, 35(May), pp. 1503–1510. doi: 10.3109/03639040903037207.
Sudke, S. G., Sakarakar, D. M. and Sudke, S. G. (2013) ‘Design and Characterization of Enteric Coated Pellets of Aspirin Using Hot-Melt Coating Technique’, International Journal of Pharma Research & Review, 2(3), pp. 1–10.
